Broken bones caused by MBD are called pathological fractures. Effectsīecause MBD weakens the affected bones, people with this disease are at risk for fractures. Osteolytic and osteoblastic metastatic bone disease occur because the different cancer cells secrete factors that interact with the naturally occurring cells in the bone and cause bone destruction, new bone formation, or both. Osteoblastic lesions are more frequently seen in spread of prostate, bladder, and stomach cancer.īreast cancer often behaves in a mixed osteolytic and osteoblastic manner. The new bone-forming, or osteoblastic lesions, causes the bone to become weak and deformed. This process is called osteolytic bone destruction, and it is common in cancers that have spread to bone from the lung, thyroid, kidney, and colon.Īlternatively, new bone can form in response to the cancer spread.
Sometimes, the tumor will lead to destruction of the bone in a particular area. In contrast, bone metastases are generally painful when they occur.Ĭancer most commonly spreads to these sites in the skeleton: Metastases to the lung and liver are often not detected until late in the course of disease because patients don't experience symptoms.
After the lung and the liver, the skeleton is the most common site of spread for cancers that begin in organs.
0 kommentar(er)
